Preimplantation Genetic Diagnosis (PGD)
The optimal condition for a successful pregnancy is a genetically normal embryo. With increasing maternal age, the risk of genetic abnormalities in oocytes increases, which reduces the chances of a successful pregnancy. Preimplantation Genetic Diagnosis (PGD) within the framework of an IVF treatment allows for the examination of the genetic material of oocytes and embryos to select embryos with normal genetic makeup for transfer.
Who benefits from testing?
- Women aged approximately 37 and older
- Couples with multiple unsuccessful IVF attempts
- Couples with known genetic alterations
- Women with recurrent miscarriages (recurrent pregnancy loss)
Which tests are distinguished?
Polar Body Diagnosis (PBD)
This method involves examining the polar bodies of the oocyte, which are formed during meiosis. This allows conclusions to be drawn about the maternally inherited genetic information of the embryo. The oocyte itself remains intact. This method is frequently used as a screening for chromosomal abnormalities in women aged 37 and older, but can also be used to detect known monogenic alterations. In Austria, polar body diagnostics is not considered preimplantation genetic diagnosis within the meaning of the Reproductive Medicine Act and is therefore not subject to the same strict legal regulations as the genetic analysis of trophectoderm cells.
More information on polar body diagnostics can be found HERE.
Preimplantation Genetic Diagnosis of the Trophectoderm (PGT)
These examinations involve taking cells from the trophectoderm, which later forms the placenta. This method allows for the determination of both maternally and paternally inherited alterations. The examination is recommended when the less invasive polar body diagnostics is insufficient, for instance, in cases of suspected chromosomal disorders or genetic alterations in the paternal genetic material. In Austria, the requirements for PGT are legally regulated in the Reproductive Medicine Act (FMedG).
More detailed information can be found HERE.
Monogenic Preimplantation Genetic Diagnosis (Monogenic PGT)
This examination specifically searches for known genetic alterations that increase the risk of severe hereditary diseases. It is a highly specialized and complex examination that must be planned and carried out individually for each case.
Who is authorized to perform these examinations?
In Austria, the requirements for Preimplantation Genetic Diagnosis (PGT) are legally regulated in the Reproductive Medicine Act (FMedG). While polar body diagnostics (PBD) can be performed in any laboratory approved under the Genetic Engineering Act, additional legal requirements, beyond laboratory approval, must be met for PGT following a trophectoderm biopsy.
HLN-Genetik GmbH is the only private laboratory in Austria approved for both PBD and PGT, including monogenic PGT.
Advantages: Increased Chances of Success
- Higher probability of a successful pregnancy.
- Reduction in miscarriage rates.
- Fewer pregnancy terminations due to genetic abnormalities.
- Lower risk of multiple pregnancies.
- Reduced risk of invasive prenatal examinations (e.g., amniocentesis).
- Support for couples with genetic risk factors in family planning.
Consultation: Support from Renowned Fertility Clinics
We have been working closely for years with a variety of renowned fertility clinics throughout Austria. These clinics offer comprehensive consultations to answer all your questions regarding preimplantation genetic diagnosis and genetic testing in the context of fertility treatment. We are happy to connect you with these specialized centers to find the best approach for you and provide optimal support throughout the entire process.