Tumour disorders
Tumour disorders comprise a wide range of genetically determined cancers that may affect various organ systems. Among the more common hereditary cancer disorders are hereditary breast and ovarian cancer syndrome and hereditary non-polyposis colorectal cancer (HNPCC).
Request Test
- Sample material: EDTA whole blood
- Test method: next-generation sequencing (NGS) (if applicable, Sanger sequencing, MLPA, molecular diagnostics by PCR)
- Turnaround time: from 2 weeks
- Required documents:
Detailed information on sample submission can be found here.
DIAGNOSTIC SERVICES
The table below presents our indication-specific testing services in this area:
| INDICATION | ANALYSIS |
| Endometrial carcinoma | Gene panel |
| Familial breast and ovarian cancer | Gene panel |
| Fanconi anaemia | Gene panel |
| Hereditary adenomatous polyposis | Gene panel |
| Hereditary non-polyposis colorectal cancer (HNPCC) | Gene panel |
| Gastric carcinoma | Gene panel |
| Melanoma | Gene panel |
| Neurofibromatosis type 1 | Single-gene analysis (NF1) |
| Neurofibromatosis type 2 | Single-gene analysis (NF2) |
| Renal carcinoma | Gene panel |
| Pancreatic carcinoma | Gene panel |
| Paraganglioma–pheochromocytoma syndrome | Gene panel |
| Prostate carcinoma | Gene panel |
| Thyroid carcinoma | Gene panel |
| Central nervous system tumour | Gene panel |
The genes analysed in the respective gene panels are always based on the current versions of the Genomics England PanelApp, the PanelApp Australia, the OMIM Phenotypic Series, and the entries in GeneReviews.
If the suspected diagnosis or indication is not listed here, or if it is a complex syndromic condition, it is possible to request exome sequencing based on phenotypic features.